Newsletter No. 97

CUHK Newsletter 4 No. 97 19th November 1996 醫 學 Medicine, Den t i s t r y an d Hea l t h 研究類別/題目 Project Title 研究員 CUHK Investigator(s) 獲撥款項(港元) Amount Approved (HK$) •幽門螺旋菌與非類固醇止痛藥引發之 消化性潰瘍硏究 Does Eradication of Helicobacter Pylori Prevent NSAID-related Ulcers and Complications 沈祖堯教授 Prof. Josep h J. Y. Sung 陳家亮醫生 Dr . Francis K. L. Chan 鍾尙志教授 Prof. Sydne y S. C. Chung 凌健華博士 Dr . Thomas K. W. Ling 鄭勳斌教授 Prof . Augustine F. B. Cheng 692,000 •首次中風病人而患有中腦動脈狹窄的 前瞻性研究 A Prospective Study of Patients with Middle Cerebral Artery Stenosis Diagnosed after First Ever Ischemic Stroke 黃家星教授 Prof . Lawrence K. S. Wong 祁理治教授 Prof . Richard L. C. Kay 區皓智教授 Prof . Anil T. Ahuja 428,000 •聚合甲種免疫球 (IgA) 與環間膜細胞對 甲種免疫球腎小球炎病理成因的影響 Interaction of Mesangial Cells with Polymeric IgA : Exploration of the Mechanism and the New Treatment of Glomerular Injur y i n IgA Nephropathy (IgAN) 黎嘉能教授 Prof . Kar-neng Lai 梁志錦先生 Mr. Josep h C. K. Leung 692,000 •香港兒童哮喘的遺傳及環境因素探查 Identification o f Genetic and Environmental Ris k Factors for Childhood Asthma in Hong Kong 梁宗存教授 Prof. Rolan d C. C. Leung 賴奇偉教授 Prof . Christopher K. W. Lai 黃永堅教授 Prof. Gar y W. K. Wong 楊匯博教授 Prof . Robert P. Young 劉德輝博士 Dr . Joseph T. F. Lau 692,000 •血管活性肽對附睪陰離子分泌的局部 旁分泌/自分泌調控 Local Paracrine/Autocrine Control of Epididymal Anion Secretion by Vasoactive Peptides 陳小章教授 Prof . Hsiao-chang Chan 黃宜定教授 Prof . Patrick Y.D . Wong 邱鄭秀文教授 Prof. Siew-boo n Cheng Chew 高永雄教授 Prof . Wing-hung Ko 773,000 •海洛英對胎兒後期腦部發育及行爲的 影響 The Effects of Prenatal Heroin Exposure on Postnatal Brain Development and Behaviour i n Rats Prof. Alfreda Stadlin 1,034,000 •腹膜透析液對腹腔間皮細胞之免疫能 力及生命力之影響 Biocompatibility o f l-lactate/pyruvat e Buffered PDS: Its Effects on the Host Defense Mechanism and Viability of the Peritoneal Mesothelial Cells 余惠賢教授 Prof. Ale x W. Y. Yu 530,000 •辨別在哺乳類動物視網膜中控制軸突 在視交叉尋找路徑的分子 Identification of the Molecular Determinants i n the Retina that Govern Axon Pathfinding in the Chiasm of Mammals 陳新安教授 Prof. Sun-o n Chan 鄭鍾淑嫻教授 Prof. Shuk-ha n Chung Cheng 562,000 •骨質疏鬆之成因——遺傳及環境因素 The Vitamin D Receptor Gene, Lifestyle Factors and the Aetiology o f Osteoporosis i n Chinese 劉明珠教授 Prof . Edith M. C. Lau 楊匯博教授 Prof . Robert P. Young 何陳雪鸚教授 Prof. Suzanne S.Y. Chan Ho 郭志良教授 Prof . Julian A. J. H. Critchley 胡令芳教授 Prof. Jea n Woo 692,000 •肥大細胞的前列腺素受體 Prostanoid Receptors on Mast Cells 劉行榕教授 Prof. Alaste r H. Y. Lau 鍾思樸教授 Prof . Robert L. Jones 562,000 •定量硏究擴髓腔技術對長管骨髓腔內 壓力及骨髓脂肪栓塞的影響 The Effect of Reaming Technique on Intramedullary Pressur e and Marrow Fat Embolization — A Quantitative Study 梁國穗教授 Prof . Kwok-sui Leung 陳振宇教授 Prof . Zhen-yu Chen 王韻娜教授 Prof . Margaret W. N. Wong 馮國培教授 Prof . Kwok-pui Fung 692,000 •成體金黃地鼠視網膜組織的長期培養 作爲神經節細胞再生硏究的模型 Long Term Culture of the Whole Retina of Adult Hamsters as a Model to Study Regeneration of Retinal Ganglion Cells 左雨鵬教授 Prof . Eric Y. P. Cho 462,000 •具病症特異性糖蛋白及糖肽激素同位 體的分離、提純和結構分析 Isolation, Purification and Structural Elucidation of Disease-specific Isoforms of Glycoproteins and Glycopeptide Hormones 莊文信教授 Prof . Philip J. Johnson 楊孟思教授 Prof. Magnu s N. Hjelm 345,000 •鼻咽癌細胞動態研究及其對臨牀治療 的意義 Cell Kinetic Studies in Undifferentiated Nasopharyngeal Carcinoma and the Implications fo r Clinical Management 陳德章教授 Prof . Anthony T. C. Chan 張文龍醫生 Dr. Pete r M. L. Teo 梁惠棠教授 Prof. Thoma s W.T. Leung 陳志強教授 Prof. Alexande r R. Chang 莊文信教授 Prof . Philip J. Johnson 594,000 研究類別/題目 Project Title 研究員 CUHK Investigator(s) 獲撥款項(港元) Amount Approved (HK$) •基因組競爭性雜交法於鼻咽癌遺傳基 因硏究之應用 The Application of Comparative Genomic Hybridization for the Detection of Genomic Imbalances in Nasopharyngeal Carcinoma 梁承暉教授 Prof . Sing-fai Leung 王昭春博士 Dr . Nathalie Wong 黃潘慧仙教授 Prof. Doll y W. S. Poon Huang 莊文信教授 Prof . Philip J. Johnson 692,000 •鼻咽癌癌前變化之病理及遺傳基因的 硏究 Molecular Pathology of the Precancerous Lesions in Nasopharyngeal Carcinoma 李川軍教授 Prof . Joseph C. K. Lee 黃潘慧仙教授 Prof. Doll y W.S . Poon Huang 杜家輝教授 Prof. Ka-fa i To 羅國煒先生 Mr. Kwok-wa i Lo 梁承暉教授 Prof . Sing-fai Leung 761,000 •降鈣素基因相關肽和一氧化氮在血管 平滑肌上的相互作用：細胞機制和內 毒素剌激的參與 Calcitonin Gene-related Peptide (CGRP) and Nitric Oxide Interactions in Vascular Smooth Muscle: Cellular Mechanisms and Involvement in Endotoxin Shock 費遠博士 Dr . Ronald R. Fiscus 859,000 •利用異體眞皮、纖維蛋白、自體表皮 細胞製成代用皮 Reconstitution of a Human Skin Equivalent Composed of Lyophilized Allogenic Dermis , Keratinocytes and Fibrin 金永強教授 Prof. Walte r W. K. King 李國章教授 Prof . Arthur K. C. Li 568,000 • Neo-adjuvan t Chemotherapy i n Squamous Oesophageal Cancer: Prediction of Chemoresponse Using Biopsy Sampl e before Chemotherapy 陳志偉醫生 Dr . Angus C. W. Chan 362,000 •利用胸腔鏡與常規剖胸施行肺楔形切 除術，對豬的新陳代謝及免疫反應的 比較硏究 A Comparative Study of the Effects of Wedge Lung Resection by Thoracoscopy versus Thoractomy on the Metabolic and Immunological Respons e in a Porcine Model 嚴秉泉教授 Prof . Anthony P. C. Yim 許永德醫生 Dr. Pete r Hewitt 何其成博士 Dr . Jonathan K. S. Ho 198,000 •利用轉基因小鼠獲得機能和缺失機能 兩變異種分析 Tlx 基因在致癌和生長發 育過程中的作用 Analysis of Tlx Gene Functions in Oncogenesis and Development Using Gain-of-function an d Loss-of-function Mutants in Transgenic Mice 鄭鍾淑嫻教授 Prof. Shuk-ha n Chung Cheng 726,000 •骨髓及周圍血幹細胞移植引致的自體 對移植物反應性疾病與細胞素狀態的 關係 The Correlation between Graft-versus-host Disease and Cytokine Profiles in Bone Marrow and Peripheral Blood Stem Cell Transplantation 阮文賓教授 Prof . Patrick M. P. Yuen 鄭鍾淑嫻教授 Prof. Shuk-ha n Chung Cheng 龐雅軒先生 Mr . Henry N. H. Pong 692,000 •免疫球蛋白基因快速突變的分子機 制：是否與脫氧核糖核酸轉錄—修補 系統相似 Molecular Mechanism of Immunoglobulin Gene Hypermutation: Does It Resemble the Transcription-DNA Repair System? 崔耀隆教授 Prof . Yiu-loon Chui 林柏良教授 Prof . Pak-leong Lim 807,000 •凝血素對免疫及抗癌作用的機制 Mechanisms Underlying the Immunomodulatory an d Antitumour Activities of Selected Lectins 廖永強教授 Prof. Ke n W. K. Liu 吳子斌教授 Prof. Tzi-bu n Ng 黃榮春教授 Prof . Vincent E.C. Ooi 張樹庭教授 Prof . Shu-ting Chang 692,000 •細胞漿生長因素對於心力衰歇病人的 心肌膠原累積的控制和對於左心室舒 張功能紊亂形成所起的作用 The Role of Cytokine Growth Factors in the Control of Myocardial Collagen Turnover and the Development of Left Ventricular Diastolic Dysfunction in Patients with Heart Failure 孫德生教授 Prof. Joh n E. Sanderson 周俊昌醫生 Dr . Louis T. C. Chow 胡錦生教授 Prof . Kam-sang Woo 692,000 •視網膜節神經細胞凋死之挽救劑 Neuronal Rescuers for Apoptotic Degeneration of Retinal Ganglion Cells 曹安民教授 Prof . Mark 0. M. Tso 林添德教授 Prof. Tim-ta k Lam 1,093,000 • 腎 Kallikrein-kinin 系統在血壓及鹽均衡 的重要性——對華人，尤其患高血壓 或糖尿病華人之硏究 The Role of the Renal Kallikrein-kinin System in the Regulation of Sodium Balance and Blood Pressure in Chinese Subjects in Relation to a Family History of Hypertension, Low/Normal Renin Hypertension or NIDDM Albuminuric Status 陳恩強教授 Prof . Thomas Y. K. Chan 陳重娥教授 Prof . Juliana C.N. Chan 楊匯博敎授 Prof . Robert P. Young 湯寧信教授 Prof . Brian Tomlinson 郭志良教授 Prof . Julian A. J. H. Critchley 929,000 •香港華人抑鬱症和神經衰弱的睡眠及 神經內分泌機制硏究 The Use of Sleep and Neuroendocrine Changes as Biological Probes of Depression and Neurasthenia in Chinese Subjects in Hong Kong 榮潤國教授 Prof . Yun-kwok Win g 李誠教授 Prof. Sin g Lee 陳佳鼎教授 Prof . Char-nie Chen 周振中醫生 Dr . Chun-chung Chow 692,000