Newsletter No. 300

第三零零期　二零零七年六月十九日 No. 300 19 June 2007 5 Name 姓名 Post 職位 Effective Date 生效日期 Name 姓名 Post 職位 Effective Date 生效日期 Honorary Appointments 名譽職務 Prof Vincent J Goossaert Visiting Professor (honorary), Dept of Cultural & Religious Studies文化及宗教研究系名譽客座教授 2.5.2007 – 31.7.2007 Prof Teo Man Lung, Peter 張文龍 Honorary Professor, Dept of Clinical Oncology 腫瘤學系榮譽教授 2.5.2007 – 1.5.2009 Dr Li Zheng 李錚 Visiting Scholar (honorary), Dept of Obstetrics & Gynaecology 婦產科學系名譽訪問學人 11.5.2007 – 10.9.2007 Dr Chan Kwong Pui 陳廣培 Research Associate (honorary), Divinity School of Chung Chi College, Dept of Cultural & Religious Studies文化及宗教研究系崇基學院神學院名譽 副研究員 12.5.2007 – 11.5.2009 Prof Wong Yung Hou 王殷厚 Adjunct Professor, Dept of Pharmacology 藥理學系 兼任教授 14.5.2007 – 13.5.2010 Dr Xu Jirong 徐紀榮 Postdoctoral Fellow (honorary), Dept of Physiology 生理學系名譽博士後研究員 16.5.2007 – 15.5.2008 Dr Liu Qing 劉擎 Research Associate (honorary), Research Centre for Contemporary Chinese Culture, Institute of Chinese Studies 中國文化研究所當代中國文化研究中心 名譽副研究員 15.6.2007 – 31.8.2008 Dr Suzanne Pepper 胡素珊 Research Fellow (honorary), Universities Service Centre for China Studies 中國研究服務中心名譽 研究員 15.6.2007 – 14.6.2009 Mr Zhang Ming 張銘 Visiting Scholar (honorary), Dept of Ophthalmology & Visual Sciences 眼科及視覺科學學系名譽訪問學人 25.6.2007 – 24.6.2010 Prof Yuen Kwok Yung 袁國勇 Honorary Professor, Faculty of Medicine 醫學院榮譽 教授 1.7.2007 – 30.6.2009 Appointments 聘任 Dr Satish P Bhat, MB BS MS DNB (GenSurg) DNB (PlasticSurg) MCh MRCSEd Visiting Scholar, Dept of Surgery 外科學系訪問學人 3.5.2007 Miss Jia Hongyan 賈紅艷, MB MM Visiting Scholar, Dept of Ophthalmology & Visual Sciences 眼科及視覺科學學系訪問學人 7.5.2007 Ms Ying Xi 應希, MB MM Visiting Scholar, Dept of Anatomy 解剖學系訪問 學人 10.5.2007 Dr Yu Ka Yin 余家燕, BSc MPhil PhD Postdoctoral Fellow, Dept of Biology 生物系博士後 研究員 11.5.2007 Miss Tjan Yuet Fong 曾月芳, BA MPhil Project Co-ordinator II, Centre for Advancement of Information Technology in Education, Hong Kong Institute of Educational Research 香港教育研究所 資訊科技教育促進中心二級計劃協調員 14.5.2007 Dr Wang Jingxue 王景雪, BAgr MS DS Postdoctoral Fellow, Dept of Biology 生物系博士後 研究員 14.5.2007 Ms Chan Yat Heung, Amany 陳一香, MB MPhil CCD Instructor II, Jockey Club Centre for Osteoporosis Care & Control, Faculty of Medicine 醫學院 賽馬會骨質疏鬆預防及治療中心二級導師 14.5.2007 Miss Chan Man Ling 陳漫玲, BSc MPhil Project Co-ordinator II, Dept of Biology & Institute of Plant Molecular Biology & Agricultural Biotechnology 生物系及植物分子生物學及農業 科技研究所二級計劃協調員 15.5.2007 Miss Shing Suet Yin 盛雪燕, BSc Project Co-ordinator II, Dept of Ophthalmology & Visual Sciences 眼科及視覺科學學系二級計劃 協調員 15.5.2007 Dr Cai Gangshu 蔡港樹, BS MEcon PhD Visiting Scholar, Dept of Systems Engineering & Engineering Management 系統工程與工程管理 學系訪問學人 16.5.2007 Miss Cheung Shui Ling 張瑞玲, BA MA Project Co-ordinator II, Dept of Ophthalmology & Visual Sciences 眼科及視覺科學學系二級計劃 協調員 18.5.2007 Ms Tu Liu 涂柳, MB MS Visiting Scholar, Dept of Paediatrics 兒科學系 訪問學人 18.5.2007 Miss Chiu Hiu Yim 丘曉艷, BA PGDE Executive Officer II, Faculty of Education 教育學院 二級助理主任 21.5.2007 Miss Lai Wan Chi 黎蘊慈, BA PGDE Executive Officer II, Business Section, Bursary 財務處 商務組二級助理主任 21.5.2007 Ms Tsui Wing Ping, Patti 徐詠萍, BA PGCertTranslat MA Executive Officer I, Dept of Ophthalmology & Visual Sciences 眼科及視覺科學學系一級助理主任 21.5.2007 Miss Yip Tsui Chi 葉翠之, BA Course Co-ordinator II, School of Continuing & Professional Studies 專業進修學院二級課程統籌 21.5.2007 Dr Xu Weijun 徐維軍, BEng MS DMgt Postdoctoral Fellow, Dept of Decision Sciences & Managerial Economics 決策科學與企業經濟學系 博士後研究員 22.5.2007 Dr Chan Suk Mei 陳淑薇, BSc PhD Research Associate, Dept of Medicine & Therapeutics 內科及藥物治療學系副研究員 28.5.2007 中 大研究人員在精子發現一個上皮細胞離子通道， 可能影響男性生育能力。 精子必須經過稱為精子獲能的啟動過程，才能使卵子受 精，這個精子獲能的過程已知是由碳酸氫鹽誘發。由陳 小章教授 ( 圖 ) 領導的上皮細胞生物學研究中心的研究人 員，與浙江醫學科學院合作，證實囊性纖維化跨膜電導 調節器 ( CFTR ) 負責輸送碳酸氫根進入精子，對精子授 精能力及男性生育能力非常重要；CFTR是一個陰離子 通道，其基因突變會導致囊性纖維化，因為氯離子和碳 酸氫根 ( HCO3- ) 分泌缺陷，引發一系列器官病徵。 百分之九十五患上囊性纖維化的男性病人，因先天性無 輸精管 ( CBAVD ) 而不育， 但囊性纖維化跨膜電導調節 器基因突變會否導致其他類型的男性不育，仍有爭議。 研究人員首次在人類和老鼠的精子發現CFTR。CFTR抑 制劑或抗體能有效減低精子獲能，以及相關的碳酸氫根 依賴反應。 研究結果顯示，精子的CFTR功能為碳酸氫根的傳輸，促 使精子獲能；而CFTR基因突變引致功能失效，會降低精 子授精能力，這是先天性無輸精管以外另一導致男性不 育的可能因素。 R esearchers at The Chinese University of Hong Kong have made another big step forward in the study of male fertility with the discovery that an epithelial ion channel, the defect of which has been previously shown to result in female infertility, was also present in sperm and affecting male fertility. The finding was published online in the recent issue of the Proceedings of National Academy of Sciences of the US. 中大發現與男性不育相關的基因突變 Discovery Sheds New Light on Male Infertility 以下項目詳情，請上網 www.cuhk.edu.hk/iso/newslter/ issue/300/discoveries.htm 閱覽： ■ Eleven Research Projects Received Grants Sperm are not able to fertilize the egg unless they go through capacitation, which is known to be stimulated by bicarbonate. The research team of Prof Chan Hsiao Chang, director of the Epithelial Cell Biology Research Centre, in collaboration with Zhejiang Academy of Medical Sciences, demonstrated that cystic fibrosis transmembrane conductance regulator (CFTR) is involved in transporting bicarbonate into sperm, and thus, is vital to sperm fertilizing capacity and male fertility. The research team reported for the first time that CFTR is detected in both human and mouse sperm. CFTR inhibitor or antibody significantly reduces sperm capacitation and the associated HCO3--dependent events. These results suggest that CFTR in sperm may be involved in the transport of HCO3- important for sperm capacitation and that CFTR mutations with impaired CFTR function may lead to reduced sperm fertilizing capacity and male infertility other than CBAVD.