Newsletter No. 115

CUHK Newsletter No. 115 4th November 1997 3 HK$72,331,980 for Research As reported in the Summer Supplement 1997 issue of the CUHK Newsletter, 132 research projects proposed by members of the University have successfully attracted earmarked grants totalling some HK$72 million from the government's Research Grants Council. The details of the projects, listed under four categories, are as follows: 生物及醫學 Biology and Medicine 研究題目 Project Title 研究員 CUHK Investigator(s) 獲撥款項(港元) Amount Approved (HK$) • A Model Lower Termite to Understand Division of Labour amongst Workers 高仕林教授 Prof. Michael W.J. Crosland 780,830 •微囊飼料對增強海水魚類幼體成活率及 發育的硏究 Evaluation of Novel Microencapsulated Formulations for the Improved Survival and Development of Cultured Marine Fish Larvae 胡應劭教授 Prof. Norman Y.S. Woo 849,500 •茶多酚降低血膽固醇機理的硏究 Investigation of Mechanisms of Cholesterol- lowering Effect of Green Tea Epicatechin Isomers 陳振宇教授 Prof. Zhen-yu Chen 方永平教授 Prof. Wing-ping Fong 1,122,000 •低密度脂蛋白作爲抗癌藥物的目標載體 Low Density Lipoprotein as Carrier for Targeted Delivery of Antitumoral Drugs •珠江河口浮游植物與浮游動物營養移轉 硏究 An in situ Study of the Phytoplankton- zooplankton Trophic Transfer in the Zhujiang River Estuary 馮國培教授 Prof. Kwok-pui Fung 黃創儉教授 Prof. Chong-kim Wong 718,680 614,520 •香港海藻營養的評估及其藥效成分的特徵 硏究 Characterization of Pharmacologically Active Substances and Nutritional Evaluation of Selected Seaweeds in Hong Kong 張志強教授 Prof. Peter C.K. Cheung 黃榮春教授 Prof. Vincent E C. Ooi 伍澤賡教授 Prof. Put O. Jr. Ang 500,000 ‧用脂肪酸激活受體缺乏的基因特變鼠作 爲硏究肥胖病的動物模型 Production of Transgenic Mice Lacking the Fatty Acid-activated Receptor: An Animal Model to Study Adipose Cell Differentiation and Obesity 李秀端教授 Prof. Susanna S.T. Lee 陳活彝教授 Prof. Wood-yee Chan 張榮泰教授 Prof. Wing-tai Cheung 960,500 ‧內皮素轉化酶的分子及免疫硏究 Molecular and Immunological Characterization of Endothelin Coverting Enzymes 溫志昌教授 Prof. David C.C. Wan 649,080 •貝類過敏源的分子硏究：克隆、順序測定 表達及免疫反應 Molecular Studies on Shellfish Allergens: Cloning, Sequencing, Expression and Immunological Responses 朱嘉濠教授 Prof.Ka-hou Chu 關海山教授 Prof. Hoi-shan Kwan 馮 明釗教授 Prof. Ming-chiu Fung 686,880 •香菇早期菇體發育中訊號傳遞基因的酵 母互補分析 Yeast Complementation Analyses of Signal Transduction Genes Isolated from Early Fruit Body Development of Shiitake Mushroom Lentinula edodes 關海山教授 Prof. Hoi-shan Kwan 780,840 •植物及菇類核糖體失活蛋白的特徵與基 因表達 Characterization and Expression of Ribosome Inactivating Proteins in Plants and Mushrooms 黃榮春教授 Prof. Vincent E C. Ooi 辛世文教授 Prof. Samuel S.M. Sun 吳子斌教授 Prof. Tzi-bun Ng 718,680 •應用及開發中國野生香菇資源 Screening Natural Populations of Chinese Shiitake Strains for Present and Future Commercial Potential 趙紹惠教授 Prof. Siu-wai Chiu 686,880 • Genetic Engineering of Sweet Protein Mabinlin for Increased Stability 辛世文教授 Prof. Samuel S.M. Sun 黃蔭成教授 Prof. Yum-shing Wong 656,640 •草菇菌絲生長及子實體形成期纖維素酶 的生產及分布 Production and Distribution of Cellulolytic Enzymes in the Edible Straw Mushroom, Volvariella volvacea, during Substrate Colonization and Fruit Body Morphogenesis 巴士威教授 Prof. J.A. Buswell 616,980 •前列腺環素受體對疼痛調節的作用 The Role of Prostacyclin Receptors in Pain Modulation 慧凱倫教授 Prof. Helen Wise 鍾思樸教授 Prof. Robert L. Jones 686,880 •亞洲病人使用攜帶式腸膜透析的治療指 標是甚麼 What is the Acceptable Dialysis Adequacy for Asian Patients Undergoing Continuous Ambulatory Peritoneal Dialysis Treatment? 黎嘉能教授 Prof. Kar-neng Lai 余惠賢教授 Prof. Alex W.Y. Yu 李錦滔醫生 Dr. Philip K.T. Li 656,530 研究題目 Project Title 研究員 CUHK Investigator(s) 獲撥款項(港元） Amount Approved (HK$) •多種抗生素耐藥的肺炎雙球菌之分子流 行病學硏究 Molecular Epidemiology of Penicillin- and Multidrug-resistant Streptococcus pneumoniae 葉碧瑤醫生 Dr. Margaret Ip 邵雅樂教授 Prof Olaf Scheel 鄭勳斌教授 Prof. Augustine F.B. Cheng 514,080 •兒茶酚舒張血管機理的硏究 Study on Mechanisms of Vasodilator Effects of Green Tea Epicatechin Isomers in Spontaneously Hypertensive Rats and Normotensive Rats 黃聿教授 Prof. Yu Huang 陳振宇教授 Prof. Zhen-yu Chen 500,000 •細胞外基質相關蛋白 SPARC 在卵巢癌的 生長和入侵所扮演的角色 The Role of SPARC, an Extracellular Matrix-associated Protein, in Ovarian Tumour Growth and Invasion 陳活彝教授 Prof. Wood-yee Chan 686,880 • Cellular Analysis of Short- and Long-term Synaptic Plasticity at Aplysia Sensory-motor Neuron Synapses in Cell Culture 包建新教授 Prof. Jian-xin Bao 686,880 •睪丸激素如何調節大白鼠附單之血管緊 張素系統 Testicular Hormone-regulated Expression of the Renin-angiotensin II System in the Rat Epididymis 梁寶成教授 Prof. Po-sing Leung 陳小章教授 Prof. Hsiao -Chang Chan 686,880 •胃癌與幽門螺旋菌：一項休止期染色體、 比較性基因雜交及分子遺傳學（包括小染 色隨體）之硏究 Gastric Cancers and Helicobacterpylori — A Combined Study by Interphase Cytogenetics, Comparative Genomic Hybridization and Molecular Genetic Analysis (Including Microsatellite Analysis) 李川軍教授 Prof. Joseph C.K. Lee 陳詠儀教授 Prof. Wing-yee Chan 羅國煒先生 Mr. Kwok-wai Lo 王昭春博士 Dr. Nathalie Wong 686,880 ‧不動桿菌基因種：在香港之分布及聚合酶 鏈反應（ PCR ) 鑒定法的評估 Acinetobacter Genospecies: Their Distribution in Hong Kong and Evaluation of PCR Identification Methods 黃亭秀教授 Prof. Elizabeth T.S. Houang 朱耀威博士 Dr. Yiu-wai Chu 686,880 •黑質抑制通道作爲控制癲癇突發系統之 電生理硏究 The Nigral GABAergic Inhibitory Pathway as an Endogenous Control System of Epileptic Seizures: An Electrophysiological Study 容永豪教授 Prof. Wing-ho Yung 535,680 •常用止咳中藥貝母的化學和藥理學硏究 Chemical and Pharmacological Studies of Beimu, a Commonly Used Antitussive Traditional Chinese Medicine 林革教授 Prof. Ge Lin 關耀華教授 Prof. Yiu-wah Kwan 何綺萍教授 Prof.Yee-ping Ho 686,880 •青光眼內視神經細胞凋謝之藥療 Therapeutics for Apoptotic Loss of Retinal Neurons in Glaucoma 林添德教授 Prof. Tim-tak Lam 曹安民教授 Prof. Mark O.M. Tso 835,070 •大鼠塞爾托利氏細胞的電解質運輸對輸 精小管液體形成的作用 Electrolyte Transport Mechanisms Underlying the Formation of Seminiferous Tubular Fluid by Rat Sertoli Cells 高永雄教授 Prof. Wing-hung Ko 陳小章教授 Prof. Hsiao -Chang Chan 686,880 •在大隱靜脈外加支架，對防止血管壁在冠 狀動脈搭橋手術後產生有害變化的功效 硏究 Investigation of the Efficacy of External Stenting of Saphenous Vein Bypass Grafts in Preventing Deleterious Graft Wall Changes Following Coronary Artery Bypass Surgery 伊薩德教授 Prof. Mohammad Bashar Izzat 嚴秉泉教授 Prof. Anthony P C. Yim 孫德生教授 Prof. John E. Sanderson 周俊昌醫生 Dr. Louis T.C. Chow 614,520 • Kupffer 氏細胞在肝硬化演變中的動態測 定，以及其在預防肝硬化轉移性肝癌中的 潛在作用 The Determination of Kupffer Cell Kinetics during the Evolution of Cirrhosis and the Potential Role of Kupffer Cells in Preventing the Development of Liver Metastases in the Presence of Cirrhosis 廖傳佳教授 Prof. Chon-kar Leow 劉允怡教授 Prof Joseph W.Y. Lau 劉宗石教授 Prof. Choong-tsek Liew 賴寶山教授 Prof. Bo-san Lai 493,560 (continued on page 4)